Throughout its history, humans have been exposed to many pathogens and xenobiotics that have posed a significant threat to their survival and procreation. Some individuals develop effective responses to control the presence of pathogens and xenobiotics in the body and facilitate their elimination, while others, on the contrary, have less suitable responses that can lead to serious consequences. While certain environmental factors partly explain this heterogeneous response, the involvement of genetic factors no longer needs to be demonstrated. It is a complex genetic control (genetic heterogeneity), to which are added interactions with specific host, pathogen and environmental factors. The research developed in this thematic axis seeks to understand the genetic factors at the origin of the differences in the response of humans to pathogens and xenobiotics. This represents an essential link in the search for new therapeutic targets and will certainly make it possible to develop new strategies for the fight against infectious diseases and for civilization.

The axis "genetic adaptation of the host" revolves around three themes: (1) Genetic and epigenetic adaptation and susceptibility to infections, (2) Biological environment and variability of response to infections and (3) Molecular basis of the response to xenobiotics.

Responsible

David Courtin

David Courtin

GENE Manager, Ghana Implementation Manager, Research Officer
Accra, Ghana
lauregineau

Laura GINEAU

GENE Manager, Research Officer
Paris, Faculty of Pharmacy

Projects

Selection
  • All
  • Theme 1: genetic adaptation and susceptibility to parasitic infections (3)
  • Theme 2: biological environment and variability of response to infections (7)
  • Theme 3: molecular basis of the response to xenobiotics (2)

Responsible

David Courtin

David Courtin

GENE Manager, Ghana Implementation Manager, Research Officer
Accra, Ghana
lauregineau

Laura GINEAU

GENE Manager, Research Officer
Paris, Faculty of Pharmacy

UMR Merit teams

Ivy Bentil

Ivy BENTIL

PhD student
Accra, Ghana
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Magalie DAMBRUN

Regulatory unit managers, Assistant engineer
Paris, Faculty of Pharmacy
CELIA

Célia DECHAVANNE

Responsible for setting up in Benin, Research Officer
Benin
ANDRE

Andrew GARCIA

Unit Director, Research Director
Paris, Faculty of Pharmacy
Ghislain Koura

Ghislain KOURA

The Union
Benin
FLORENCEMN

Florence MIGOT-NABIAS

Deputy Director of the UMR, Director of Research
Paris, Faculty of Pharmacy
Jacqueline MILET

Jacqueline MILET

IT & Digital Data Referent, Research Engineer
Paris, Faculty of Pharmacy
avatar man

Gabriel MOUAHID

University Lecturer
Benin
Audrey

Audrey SABBAGH

University Lecturer
Paris, Faculty of Pharmacy
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Mariama SOUFFOU

PhD student
Paris, Faculty of Pharmacy