PEXCELV: Extracellular vesicles: contribution to the pathogenesis of cerebral malaria and source of biomarkers and therapeutic targets

Studies have shown that extracellular vesicles (EVs), derived from Plasmodium-infected red blood cells (iRBCS), play a role
important in the pathogenesis of cerebral malaria (NP). In this project, we will study the nature and content of EVs to determine their
role in the pathogenesis of severe malaria (PG) and NP. We offer a multidisciplinary approach combining information
biophysics and proteomics at the single particle level by tracking analysis of nanoparticles, phenotypic analysis on EVs
immunocaptured, electron microscopy and biomolecular signature by Raman spectroscopy to characterize EVs from
of patient samples (plasmas and iEs). We will also study the functions of these EVs in primary endothelial cells and
astrocytes of human origin to define their contributions to the pathogenesis of NP.