MERIT - UMR 261 is affiliated with 2 doctoral schools:

ED 563 (drugs, toxicology, chemistry, imaging), Paris Descartes, Paris Diderot and Paris 13
ED 393 (Public health: epidemiology & biomedical information sciences), Paris Descartes, Pierre and Marie Curie, Paris Diderot

MERIT - UMR 261 is a host laboratory for M1 and M2 public health from Bordeaux 2, Paris Sud, Pasteur/CNAM, EHESP, as well as for M1 and M2 Molecular and Cellular Biology from UPMC, Biology of reproduction and development from the University of Paris Diderot, of medicine from the University of Paris Descartes.

It is also an internship site for public health interns.

Theses defended: 

  • Sebastien Dechavanne, Elucidate and circumvent immune tolerance to Malaria

Theses in progress:

  • Ayman Ztouti, Prospecting for new antimalarials for Artemisia spp. : bio-guided approach of "hits" compounds targeting chemo-refractory parasitic stages.
  • Azza Bouzaiene, Study of gametocytogenesis during bouts of Plasmodium falciparum malaria and their treatment.
  • Lucille Hervé, Biochemical and structural characterization of the interactions of quinazoline derivatives with their potential targets in P. falciparum, with a view to optimizing molecules for antimalarial purposes.
  • Jeremy Fraering, Characterization of biological processes at the Host-Parasite interface by joint study of erythrocyte and plasma proteomes in the context of Plasmodium falciparum infection.
  • Mahugnon Léger Erasmus Gbaguidi, Consequences of HLA-G expression on immune response directed to P. Falciparum in young children.
  • Valentin Joste, Study of the genetic diversity and clonality of Plasmodium ovale spp.
  • Mariama Souffou, Toxoplasma gondii and Plasmodium falciparum: exploration of cross-reactivities for characterization of IgG specific to Toxoplasma in the context of congenital infection.
  • Euripides Avokpaho, Study of risk factors for infection by soil-transmitted helminths in southern Benin.
  • Djelili Biaou, Identification of molecules involved in the immune rolerance mechanism.
  • Océane Minka, Dynamics and determinants of asymptomatic carriage of malaria in Benin.
  • Darius Sossou, Dysfunction of regulatory T and B lymphocytes associated with the risk of neonatal sepsis. 
  • Romeo Zoumenou, Neurocognitive development of children from birth to ten years in Benin, Allada cohort.

Other frameworks: 

  • Shilpa Vengatramane (3rd)
  • Brahim Benhamma (BTS)
  • Francine Ghislaine Toko Tchokoteu (M1)
  • Camille Arthur (M2)
  • Rodeline Telfils (M2)
  • Lina Boumediene (M2)
  • Yassine Louraoui (M2)
  • Iris Gomez (M2)
  • Georges El Khoury (M2)
  • Cecile Vernotte (M2 CISE)
  • Kabisha Sivakumaran (L1)
  • Theres Paramby (L3)
  • Imane Tabet (DFGSP3)
  • Camille Kepeklian (PUBLIC HEALTH DES)
  • Ines Besnard (FI 2nd year)
  • Djinn Bruand Petit (L3)

Theses defended: 

  • Laurine Rondepierre, Biochemical study of the propeller domain of the protein PIK 13 involved in the resistance of plasmodium falciparum to arthemisinimates.
  • Tatiana Hountohotegbe, Immunogenicity of a vaccine candidate against pregnancy-associated malaria: cellular immune responses induced by the PAMVAC antigen during a phase LB trial.
  • Antoinette Keita, Search for new antimalarials targeting the hepatic phase of plasmodium falciparum: Study of simplified analogues in series of tazopsin.
  • Emilie Guillochon, Identification of conserved protein motifs with high vaccine potential within the PfEMP1 antigenic family associated with cerebral malaria.

Theses in progress:

  • Ayman Ztouti, Prospecting for new antimalarials for Artemisia spp. : bio-guided approach of "hits" compounds targeting chemo-refractory parasitic stages.
  • Azza Bouzaiene, Study of gametocytogenesis during bouts of Plasmodium falciparum malaria and their treatment.
  • Lucille Hervé, Biochemical and structural characterization of the interactions of quinazoline derivatives with their potential targets in P. falciparum, with a view to optimizing molecules for antimalarial purposes.
  • Jeremy Fraering, Characterization of biological processes at the Host-Parasite interface by joint study of erythrocyte and plasma proteomes in the context of Plasmodium falciparum infection.
  • Diana Roman, Identification of molecular targets of the antimalarial drug primaquine in the malaria agent Plasmodium falciparum.
  • Stephanie Mahame, Pharmaceutical representatives in Benin and their activities in promotion and distribution. Contribute to the study of the social construction of drug markets in Africa.
  • Mahugnon Léger Erasmus Gbaguidi, Consequences of HLA-G expression on immune response directed to P. Falciparum in young children.
  • Sebastien Dechavanne, Elucidate and circumvent immune tolerance to Malaria
  • Valentin Joste, Study of the genetic diversity and clonality of Plasmodium ovale spp.
  • Mariama Souffou, Toxoplasma gondii and Plasmodium falciparum: exploration of cross-reactivities for characterization of IgG specific to Toxoplasma in the context of congenital infection.
  • Euripides Avokpaho, Study of risk factors for infection by soil-transmitted helminths in southern Benin.

Other frameworks: 

  • Marie Verbeeck (BTS)
  • Remy Account (BTS)
  • Gregoire Perriguey (BTS)
  • Eugenie Baud (BTS)
  • Alejandro Rojaschaves (M2)
  • Deborah Matondo (M1)
  • Barbara Albero (M1)
  • Laila Aboutine (L3)
  • Faiza Talibi (L3)
  • Sara Shaik (L3)
  • Samet Karakulah (BTS)
  • Dan Tarcy (BTS)
  • Remi Dumas (L3)
  • Maxime Le Roux (BTS)
  • Quiterie Boyer-Vida (M1)
  • Hortense Marie Vistoire Pigasse (L2)

Theses defended:

  • Sem Ezinmegnon, Effects of the regulation of TLRs in the neonatal immune response to Gram-negative infections in malaria-endemic areas.
  • Atikatou Mama, Adaptive evolution in Ghanaian Plasmodium falciparum isolates during Intermittent Preventive Treatment in Pregnancy - a genomic study.

Theses in progress: 

  • Lucille Hervé, Biochemical and structural characterization of the interactions of quinazoline derivatives with their potential targets in P. falciparum, with a view to optimizing molecules for antimalarial purposes.
  • Jeremy Fraering, Characterization of biological processes at the Host-Parasite interface by the joint study of erythrocyte and plasma proteomes in the context of infection with Plasmodium falciparum.
  • Laurine Rondepierre, Biochemical study of the propeller domain of the protein PIK 13 involved in the resistance of plasmodium falciparum to arthemisinimates.
  • Diana Roman, Identification of the molecular targets of the antimalarial drug primaquine in the malaria agent Plasmodium falciparum.
  • Antoinette Keita, Search for new antimalarials targeting the hepatic phase of plasmodium falciparum: study of simplified tazopsin serial analogues.
  • Stephanie Mahame, Pharmaceutical representatives in Benin and their activities in promotion and distribution. Contribute to the study of the social construction of drug markets in Africa.
  • Tatiana Hountohotegbe, Study of the immune responses induced by a vaccine against malaria associated with pregnancy.
  • Emilie GUILLOCHON, Identification of conserved protein motifs with high vaccine potential within the PfEMP1 antigenic family associated with cerebral malaria.
  • Abdou Khadre FALL, Targets and mechanisms of action of immunoglobulins G associated with protection against malaria.
  • Mahugnon Léger Erasmus GBAGUIDI, Consequences of HLA-G expression on immune response directed to P. Falciparum in young childre.
  • Sebastien DECHAVANNE, Elucidate and circumvent immune tolerance to Malaria.
  • Valentin JOSTE, Study of the genetic diversity and clonality of Plasmodium ovale spp.
  • Mariama SOUFFOU, Toxoplasma gondii and Plasmodium falciparum: exploration of cross-reactivities for characterization of IgG specific to Toxoplasma in the context of congenital infection.
  • Euripides AVOKPAHO, Study of risk factors for infection by soil-transmitted helminths in southern Benin.

Other frameworks:

  • Imtinane Ahmed-Fouatih (BTS)
  • Kevin Charlo (M2)
  • Lucille Herve (M2)
  • Sonia Nedjam (M1)
  • Ulcie Koty (M2)
  • Diariatou Diaby (M2)
  • Cloen Lhomme (M1)
  • Gueda Agne (L2)
  • Olfat Hamade (M2)
  • Justine Manso (L3)
  • Eugenie Baud (BTS)
  • Juliette Brochet (L3)
  • Lawrence Palazzo (DFGSP3)
  • Marine Gougeon (DFGSP3)
  • Gregoire Perriguey (BTS)
  • Agnes Gueda (L2)

Theses defended:

  • Leonidas Tokplonou, Impact of Schistosoma haematobium infection on HLA-G expression, and on PF malaria and specific IgG response in children in the South.
  • Jacqueline Milet, Whole genome association study in cohorts of young children in Benin.
  • Cornelia Hounkonnou, Determinants of the dynamics of submicroscopic malaria infections during pregnancy, impact of control strategies and consequences on the health of mothers and newborns in Benin.
  • Edwige Apetoh, Therapeutic practices and consumption of pharmaceutical drugs in households in Cotonou, Benin: between low attendance of health structures and extensive use of informal circuits.

Theses in progress:

  • Laurine Rondepierre, Biochemical study of the propeller domain of the protein PIK 13 involved in the resistance of plasmodium falciparum to arthemisinimates.
  • Diana Roman, Identification of molecular targets of the antimalarial drug primaquine in the malaria agent Plasmodium falciparum.
  • Antoinette Keita, Search for new antimalarials targeting the hepatic phase of plasmodium falciparum: study of simplified tazopsin serial analogues.
  • Tatiana Hountohotegbe, Study of the immune responses induced by a vaccine against pregnancy-associated malaria.
  • Stephanie Mahame, Pharmaceutical representatives in Benin and their activities in promotion and distribution. Contribute to the study of the social construction of drug markets in Africa.
  • Sem Ezinmegnon, Effects of TLRs regulation in the neonatal immune response to Gram-negative infections in malaria-endemic areas.
  • Atikatou Mama, Adaptive evolution in Ghanaian Plasmodium falciparum isolates during Intermittent Preventive Treatment in Pregnancy - a genomic study.
  • Emilie Guillochon, Identification of conserved protein motifs with high vaccine potential within the PfEMP1 antigenic family associated with cerebral malaria.
  • Abdou Khadre FALL, Targets and mechanisms of action of immunoglobulins G associated with protection against malaria.
  • Mahugnon Léger Erasmus Gbaguidi, Consequences of HLA-G expression on immune response directed to P. Falciparum in young children.
  • Sebastien Dechavanne, Elucidating and circumventing the immune tolerance to Malaria.
  • Valentin Joste, Study of the genetic diversity and clonality of Plasmodium ovale spp.
  • Mariama Souffou, Toxoplasma gondii and Plasmodium falciparum: exploration of cross-reactivities for characterization of IgG specific to Toxoplasma in the context of congenital infection.
  • Euripides Avokpaho, Study of risk factors for infection by soil-transmitted helminths in southern Benin.

Other frameworks:

  • Anne-Emmanuelle Louis Joseph (BTS)
  • Clara Couto (BTS)
  • Eliot Murbach Studer (BTS)
  • Mathilde Patat (BTS)
  • Valentin Blin (BTS)
  • Abena Praba Prah (M1)
  • Anis Mansouri (M2)
  • Hajar Ahachad (M2)
  • William Boiledieu (M2)

Theses defended:

  • Bernard Tornyigah, Malaria prevention in pregnancy: Challenges of Intermittent Preventive Treatment and Future Perspectives on Prevention Strategy.
  • Romain Coppee, Bioinformatics study of the PfK13 and PfCRT proteins involved in the resistance of plasmodium falciparum to antimalarial drugs.
  • Gino Agbota, Early maternal determinants of child health in the first months of life in Africa.
  • Jessica Pourraz, Regulating and producing drugs against malaria in Ghana and Benin: a matter of state? Pharmaceutical policies, quality standards and drug markets.
  • Margaux Chauvet, Study of the modulation by hemoglobin S of the presentation of plasmodial antigens on the erythrocyte surface and of the immune protection against malaria.

Theses in progress:

  • Laurine Rondepierre, Biochemical study of the propeller domain of the protein PIK 13 involved in the resistance of plasmodium falciparum to arthemisinimates.
  • Diana Roman, Identification of molecular targets of the antimalarial drug primaquine in the malaria agent Plasmodium falciparum.
  • Antoinette Keita, Search for new antimalarials targeting the hepatic phase of plasmodium falciparum: study of simplified tazopsin serial analogues.
  • Edwige Apetoh, Access to antimalarial treatments in Benin and Ghana: impact of health care systems on access to drugs for populations.
  • Jacqueline Milet, Whole genome association study in cohorts of young children in Benin.
  • Leonidas Tokplonou, Impact of Schistosoma haematobium infection on HLA-G expression, and on PF malaria and the specific IgG response in children in the south.
  • Tatiana Hountohotegbe, Study of the immune responses induced by a vaccine against pregnancy-associated malaria.
  • Sem EZINMEGNON, Effect of the regulation of TLRs in the neonatal immune response to Gram-negative infections in malaria-endemic areas.
  • Stephanie Mahame, Pharmaceutical representatives in Benin and their activities in promotion and distribution. Contribute to the study of the social construction of drug markets in Africa.
  • Atikatou MAMA Mama, Adaptive evolution in Ghanaian Plasmodium falciparum isolates during Intermittent Preventive Treatment in Pregnancy - a genomic study.
  • Cornelia HOUNKONNOU, Determination of the dynamics of submicroscopic malaria infections during pregnancy, impact of control strategies and consequences on the health of mothers and newborns in Benin.
  • Emilie GUILLOCHON, Identification of conserved protein motifs with high vaccine potential within the PfEMP1 antigenic family associated with cerebral malaria.
  • Abdou Khadre FALL, Targets and mechanisms of action of immunoglobulins G associated with protection against malaria.
  • Euripides AVOKPAHO, Study of risk factors for infection by soil-transmitted helminths in southern Benin.

Other frameworks:

  • Sami Guemouri (3rd discovery)
  • Paul Lesage (3rd discovery)
  • Lucille Breard (BTS)
  • Clara Couto (BTS)
  • Theana Fassier (BTS)
  • Abdou Khadre Fall (M2)
  • Lisa Casanas (DFGSP2)
  • Sabrine Hadji (BTS)
  • Marianne Lecat (DFGSP3)
  • Carine Berberi (M1)
  • Celina Mayinga (SUP'BIOTECH)
  • Aicha Hramch (M2)
  • Shona Gray - Switzman (M2)
  • Leslye Morel (BTS)
  • Valention Joste (M2)