We recently observed that children born to mothers infected with Pf during pregnancy have dysregulated immunity 2 years after birth. In order to explain the mechanisms related to the long-term effects of maternal Pf infection on infant immunity, we hypothesize that maternal Pf infection reprograms neonatal stem cells to constrain them, they and the specialized immune cells that will arise from them, to be weak responders. Epigenetic modifications that regulate gene expression are known to be associated with such reprogramming.
Therefore, the epigenetic modifications of the progenitor cells and the consequent functional capacities of the cells will be determined.
Northern Partnership
- Cochin Institute
- Case Western Reserve University
Southern Partnership
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2022-2023
